Tuttle KR, Bakris GL, Bilous RW, Chiang JL, de Boer IH, Goldstein-Fuchs J, Hirsch IB, Kalantar-Zadeh K, Narva AS, Navaneethan SD, Neumiller JJ, Patel UD, Ratner RE, Whaley-Connell AT, Molitch ME. Diabetes Care. 2014; 37(10):2864-83.
Nasri H, Ardalan MR, Rafieian-Kopaei M. Mechanistic Impacts of Medicinal Plants in Diabetic Kidney Disease. Iran J Public Health. 2014 Sep; 43(9):1311-3.
Herbal medicines have been traditionally used for the treatment of diabetes mellitus. Some medicinal plants contain compounds that can be effective in impaired glucose tolerance. Recent pre-clinical and clinical trials have also demonstrated their beneficial effects on diabetes associated complications, especially on diabetic nephropathy. Although some plants have been shown to have toxic effects, hut several species with beneficial effects on diabetes mellitus and in the prevention of kidney complications in diabetic patients have been identified. These effects have been observed with both bioactive compounds and crude extracts isolated from anti-diabetic plants. In particular, plants such as Sclerocarya birrea, Persea americana, Ficus thonningii and Helichrysium ceres have been shown to have renoprotective effects. Isolated compounds such as oleanolic acid have also been shown to possess renoprotective effects in experimental diabetes in animals. Hence oleanolic acid caused an increase in renal Na+ excretion in streptozotocin-induced diabetic rats, which was mediated by an improvement in glomerular filtration rate , read the story